Document Classification Systems in Heterogeneous Computing Environments

Datacenter workloads demand high throughput, low cost and power efficient solutions. In most data centers the operating costs dominates the infrastructure cost. The ever growing amounts of data and the critical need for higher throughput, more energy efficient document classification solutions motivated us to investigate alternatives to the traditional homogeneous CPU based implementations of document classification systems. Several heterogeneous systems were investigated in the past where CPUs were combined with GPUs and FPGAs as system accelerators. The increasing complexity of FPGAs made them an interesting device in the heterogeneous computing environments and on the other hand difficult to program using Hardware Description languages. We explore the trade-offs when using high level synthesis and low level synthesis when programming FPGAs. Using low level synthesis results in less hardware resource usage on FPGAs and also offers the higher throughput compared to using HLS tool. While using HLS tool different heterogeneous computing devices such as multicore CPU and GPU targeted. Through our implementation experience and empirical results for data centric applications, we conclude that we can achieve power efficient results for these set of applications by either using low level synthesis or high level synthesis for programming FPGAs

SHARC: Space Habitat, Assembly and Repair Center

Integrated Space Systems (ISS) has taken on the task of designing a Space Habitat, Assembly and Repair Center (SHARC) in Low Earth Orbit to meet the future needs of the space program. Our goal is to meet the general requirements given by the 1991/1992 AIAA/LORAL Team Space Design competition with an emphasis on minimizing the costs of such a design. A baseline structural configuration along with preliminary designs of the major subsystems was created. Our initial mission requirements, which were set by AIAA, were that the facility be able to: support simultaneous assembly of three major vehicles; conduct assembly operations and minimal extra vehicular activity (EVA); maintain orbit indefinitely; and assemble components 30 feet long with a 10 foot diameter in a shirtsleeve environment

Initial Design of a W-Band Superconducting Kinetic Inductance Qubit

Superconducting qubits are widely used in quantum computing research and industry. We describe a superconducting kinetic inductance qubit (and introduce the term Kineticon to describe it) operating at W-band frequencies with a nonlinear nanowire section that provides the anharmonicity required for two distinct quantum energy states. Operating the qubits at higher frequencies may relax the dilution refrigerator temperature requirements for these devices and paves the path for multiplexing a large number of qubits. Millimeter-wave operation requires superconductors with relatively high T_c, which implies high gap frequency, 2 Δ/h , beyond which photons break Cooper pairs. For example, NbTiN with T_c = 15K has a gap frequency near 1.4 THz, which is much higher than that of aluminum (90 GHz), allowing for operation throughout the millimeter-wave band. Here we describe a design and simulation of a W-band Kineticon qubit embedded in a 3-D cavity. We perform classical electromagnetic calculations of the resulting field distributions

Associations of cortisol/testosterone and cortisol/sex hormone-binding globulin ratios with atherosclerosis in middle-age women

AbstractBackground and aimsThe cortisol/testosterone (C/T) ratio has been hypothesized to be a better predictor of atherosclerosis than cortisol alone. No study has assessed whether the C/T and C/sex hormone-binding globulin (SHBG) ratios are associated with atherosclerosis in a U.S. population sample.MethodsThis substudy included 367 women who had both cortisol from year 15 and testosterone and SHBG at year 16 of the Coronary Artery Risk Development in Young Adults study, an ongoing observational cohort in the United States. Of these, intima-media thickness (IMT) was available at follow-up year 20 in 339 (n = 332 with measurement at carotid bulb), and 303 were free of prevalent coronary artery calcium (CAC) at year 15. Area under the curve (AUC) of salivary cortisol was available in 302 individuals. Ratios of AUCs of cortisol to total testosterone, free testosterone, and SHBG were categorized into tertiles. Associations with CAC and IMT were assessed by regression models adjusted for age, race, body mass index, systolic blood pressure, menopause, oral contraceptive use, diabetes, alcohol, and smoking.ResultsOnly the highest tertile of the AUC/free testosterone ratio was positively associated with carotid bulb IMT (β = 0.088, P = 0.006). This tertile was also positively associated with new onset CAC between year 15 and 25 (OR 3.45, 95% CI 1.18–10.06). Tertiles of cortisol or testosterone alone were not associated with new onset CAC.ConclusionAUC/Free testosterone ratio may be more associated with atherosclerosis in women than either indicator alone. The ratio may serve as a suitable biomarker of cortisol-linked stress

Tandem quadruplication of HMA4 in the zinc (Zn) and cadmium (Cd) hyperaccumulator noccaea caerulescens

Zinc (Zn) and cadmium (Cd) hyperaccumulation may have evolved twice in the Brassicaceae, in Arabidopsis halleri and in the Noccaea genus. Tandem gene duplication and deregulated expression of the Zn transporter, HMA4, has previously been linked to Zn/Cd hyperaccumulation in A. halleri. Here, we tested the hypothesis that tandem duplication and deregulation of HMA4 expression also occurs in Noccaea. A Noccaea caerulescens genomic library was generated, containing 36,864 fosmid pCC1FOSTM clones with insert sizes ~20–40 kbp, and screened with a PCR-generated HMA4 genomic probe. Gene copy number within the genome was estimated through DNA fingerprinting and pooled fosmid pyrosequencing. Gene copy numbers within individual clones was determined by PCR analyses with novel locus specific primers. Entire fosmids were then sequenced individually and reads equivalent to 20-fold coverage were assembled to generate complete whole contigs. Four tandem HMA4 repeats were identified in a contiguous sequence of 101,480 bp based on sequence overlap identities. These were flanked by regions syntenous with up and downstream regions of AtHMA4 in Arabidopsis thaliana. Promoter-reporter b-glucuronidase (GUS) fusion analysis of a NcHMA4 in A. thaliana revealed deregulated expression in roots and shoots, analogous to AhHMA4 promoters, but distinct from AtHMA4 expression which localised to the root vascular tissue. This remarkable consistency in tandem duplication and deregulated expression of metal transport genes between N. caerulescens and A. halleri, which last shared a common ancestor >40 mya, provides intriguing evidence that parallel evolutionary pathways may underlie Zn/Cd hyperaccumulation in Brassicaceae